Nanosurf Flex-ANA — AFM for force mapping

  • Automated nanomechanical analysis of large/multiple samples
  • Measure elasticity, stiffness, adhesion, and indentation
  • Autonomous data handling through intelligent software
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The perfect tool for fully automated nanomechanical data acquisition and analysis

The Nanosurf Flex-ANA system is an automated solution for AFM-based nanomechanical analysis. It is designed to investigate the nanomechanical properties of materials such as cells, tissues, scaffolds, hydrogels, and polymers on multiple or large samples via force spectroscopy and force mapping in an intuitive and automated fashion.

Key features and benefits

  • Automated nanomechanical analysis of large or multiple samples
  • Measure elasticity, stiffness, adhesion, and indentation according to various models
  • Intelligent software autonomously handles demanding measurements
  • Accomodates height differences of up to 5 mm and force curves with up to 100 µm in Z
  • Analysis software for easy comparison of large and complex data sets included

Nanomechanical analysis of large or multiple samples

The combination of a straight-forward experimental and post-processing workflow, selected hardware elements, and thought-through, well-designed control algorithms are hallmarks of the Flex-ANA system. Measurement locations on large or multiple samples are defined using an overview image with a large field-of-view that covers the entire accessible 32 mm × 32 mm sample area. Height differences of up to 5 mm can be overcome automatically by the system!

Schematic Flex-ANA workflow: from measurements to data analysis and comparison (left). Corresponding Flex-ANA measurement software (top right) and analysis software (bottom right).

Intelligent software autonomously deals with demanding samples

During an experiment, smart algorithms coordinate the movement of the scan head and the motorized XYZ translation stage (32 mm × 32 mm × 5 mm range), which can optionally be equipped with an additional 100-µm Z piezo for an extended spectroscopy range. To cope with large sample height variations, proprietary algorithms permanently monitor and optimize the sample position with respect to the probing cantilever and drive all Z elements accordingly. Thus, soft and sticky samples, as well as samples with macroscopic and microscopic roughness in the range of several millimeters and micrometers, respectively, can be easily addressed.

Software for advanced analysis and comparison of large, complex data sets

Besides conducting automated nanomechanical measurements, the Flex-ANA system offers advanced data post-processing and analysis capabilities:

Flex-ANA analysis software

Large data sets are automatically organized and can be batch processed and analyzed using a variety of standard contact mechanics models.

Individual force curves inside maps can be reviewed, and proprietary force curve quality control helps exclude data compromised by e.g. undesired sample contact or contamination.

Results from independent measurements can be analyzed, filtered, and pooled into data sets according to your criteria.

Entire data sets can then easily be compared to other data sets and evaluated statistically.

  • Automated Nanomechanical Characterisation
  • Tissue Nanomechanics
  • Polymer Characterisation
  • Living Cell Analysis
Components and Accessories
  • FlexAFM scan head
  • C3000 controller
  • ATS 204 automated translation stage
  • Isostage vibration isolation table
  • 5 MP Overview Camera
  • Dedicated PC for data acquisition and analysis
  • Flex-ANA measurement and analysis software
  • Optional 100-µm Z-actuator